3DO Games(s)
| Game | Region | Code | Type | Developer | Publisher | Release Date | Local Title | Rarity |
|---|---|---|---|---|---|---|---|---|
| Sample This! | NA | Demodisc | Crystal Dynamics | Crystal Dynamics | 1994 | 1 | ||
| Samurai Shodown | EU | Fighting | Crystal Dynamics | Crystal Dynamics | 1995 | 1 | ||
| Samurai Shodown | NA | Fighting | Crystal Dynamics | Crystal Dynamics | 1995 | 1 | ||
| Samurai Shodown | JP | FZ-SJ3155 | Fighting | Crystal Dynamics | Crystal Dynamics | 1995 | サムライ・ショーダウン | 1 |
| San Diego Zoo Presents: The Animals! | NA | Non-game, Edutainment | Arnowitz Studios | The Software Toolworks | 1993 | 1 | ||
| Sangokushi IV | JP | Turn-based strategy | Koei | Koei | March 24, 1995 | 三國志Ⅳ | 1 | |
| Scramble Cobra | EU | FZ-SE0404 | Combat flight simulation | Genki | Panasonic | 1995 | 1 | |
| Scramble Cobra | NA | FZ-SM0404 | Combat flight simulation | Genki | Panasonic | 1995 | 1 | |
| Scramble Cobra | JP | FZ-SJ0404 | Combat flight simulation | Genki | Panasonic | 1995 | スクランブル・コブラ | 1 |
| Scramble Cobra - Premium Version | JP | Combat flight simulation | Genki | Panasonic | 1995 | スクランブルコブラ プレミアムバージョン | 1 | |
| Scramble Cobra - Demo | JP | FZ-JJ9DSP-5G | Demodisc | Genki | Panasonic | 1995 | 1 | |
| Seal of the Pharaoh | NA | FZ-SM1751 | Dungeon crawl, Role-playing game | System Sacom | Panasonic | 1994 | 1 | |
| Secre: Fumin no Omocha Hako | JP | FZ-SJ2651 | Non-game | Glams Interactive Labo | Glams Interactive Labo | August 27, 1994 | セクレ・フーミンのおもちゃ箱 | 1 |
| Seimei Handan | JP | FZ-SJ4053 | Non-game | Ariadne | Ariadne | February 17, 1995 | 姓名判断 | 1 |
| Sento Monogatari: Sono I | JP | FZ-SJ4054 | Non-game | Byse Inc | Ariadne | October 27, 1995 | 「占都物語」 そのⅠ | 1 |
| Sesame Street: Numbers | NA | Edutainment, Mini-games | Viridis Corporation | Electronic Arts | 1994 | 1 | ||
| Sesame Street: Numbers | JP | FZ-SJ1664 | Edutainment, Mini-games | Viridis Corporation | Electronic Arts | 1994 | セサミ・ストリート ～ナンバーズ～ | 1 |
| Sewer Shark | EU | Rail shooter | Digital Pictures | Hasbro | 1994 | 1 | ||
| Sewer Shark | NA | Rail shooter | Digital Pictures | Hasbro | 1994 | 1 | ||
| Sex | EU | Non-game, Adult, Interactive movie | Vivid Interactive | Vivid Interactive | 1995 | 1 | ||
| Sex | NA | Non-game, Adult, Interactive movie | Vivid Interactive | Vivid Interactive | 1995 | 1 | ||
| Shadow: War of Succession | NA | Fighting | Tribeca Digital Studios | Tribeca Digital Studios | 1994 | 1 | ||
| Shadow: Warriors | JP | FZ-SJ0155 | Fighting | Tribeca Digital Studios | Tribeca Digital Studios | 1994 | シャドー・ウォリアー | 1 |
| Shanghai: Banri no Choujou: The Great Wall | JP | FZ-SJ1660 | Puzzle | Activision,Success | Activision | December 13, 1994 | 上海 ～万里の長城～ | 1 |
| Shanghai-Triple Threat | NA | Puzzle | Activision,Success | Activision | December 13, 1994 | 1 | ||
| Shelley Duvall's It's a Bird's Life | NA | Edutainment, Mini-games | Sanctuary Woods | Sanctuary Woods | 1993 | 1 | ||
| Quarantine | NA | First-person shooter, Racing, Vehicular combat | Imagexcel | GameTek | 1994 | 1 |